These complex pharmacological activities explain the different clinical effects ( i.e., anxiolytic, hypnotic, anticonvulsant, amnestic, and muscle relaxant) of BZDs. As a result, maximal currents elicited by GABA remain unaffected, and the GABA concentration channel opening curve is shifted to lower GABA concentrations’ chloride channel that hyperpolarizes the cell and accounts for GABA’s inhibitory effect throughout the central nervous system. This alteration, in turns, induces a conformational change in the GABA A receptor such as to increase the apparent affinity for channel gating by GABA at both agonist sites. BZDs bind to the pocket created by α and γ subunits and induce a conformational change in the GABA A receptor. The GABA A receptor is a ligand-gated chloride-selective ion channel build-up of five subunits: two α, two ß (the binding site for endogenous neurotransmitter) and one γ.
GABA represents the main inhibitor neurotransmitter in the brain and plays an important role in modulating the activity of many neurons, including those in the amygdala and prefrontal cortex.
Mazzini”, ASL 4 Teramo, Italyīenzodiazepines (BZDs) act as positive allosteric modulators on the gamma-aminobutyric acid (GABA) A receptor. D’Annunzio”, Chieti, Italy 10NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Marconi Telematic University, Rome, Italy 7Addictions Observatory (ODDPSS), Rome, Italy 8Mental Health Department - ASL Roma 2, Rome, Italy 9Department of Neuroscience, Imaging and Clinical Science, Chair of Psychiatry, University of “G. This is my first post on askubuntu (woo!) and I'm not extremely familiar with Linux yet, so brownie points will go towards anyone who can explain what they're doing in essentially layman's terms.1Psychopharmacology, Drug Misuse and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, AL10 9AB, Herts, UK 2Department of Clinical Neurosciences/DIMSC, School of Medicine, Section of Psychiatry, Polytechnic University of Marche, Ancona, Italy 3Polyedra, Teramo, Italy 4Swansea University Medical School, Ysgol Feddygaeth Prifysgol Abertawe, UK 5NESMOS Department (Neurosciences, Mental Health and Sensory Organs), Sapienza University - Rome, School of Medicine and Psychology Sant’Andrea Hospital, Rome, Italy 6School of psychology - G. This has been a problem since I first installed Ubuntu 16.04, and I haven't tried any earlier versions on this laptop. All "soft clicks" work perfectly, no bouncing. Other notes for diagnosis: If I hard click the right side of the touchpad to perform a right click, it'll record me right clicking then immediately left clicking. Any advice on this is welcome, and I'd actually settle for disabling the option to hard click the touchpad entirely ( synclient ClickPad=0 didn't do it). MaxTapTime, SingleTapTimeout, ClickTime) and tried to change the setting for "TouchpadOff" (it's currently set at 2 and I tried synclient TouchpadOff=0) to no effect.Īfter reading through some of the man pages and xorg documentation, I've learned that there's an option in some prior versions to disable "FastTaps", which sounds like it could be part of the problem. I then tried some of the settings in synclient (e.g. I first tried changing the settings through the Unity Mouse options and learned that by setting my double-click speed to absurdly high, I can get it to register as two separate single-clicks rather than a double-click, but that didn't solve the problem of the mouse bouncing. This is apparently a common problem in external mice, called "bouncing" or "rubbing" (via here), but I don't know what to do when it's a problem with the touchpad.
I'm dual booting Ubuntu 16.04 and Windows 10 on a Lenovo Yoga 13, and about half the time when I do a "hard click", that is, when I actually depress the left half of the touchpad until it clicks, it will react as if I've double clicked and registers two ButtonPress events according to xev.
So, I've been dealing with this problem for a while and decided to do something about it today.